Why Metronidazole Is Active against both Bacteria and Parasites
نویسندگان
چکیده
منابع مشابه
Why metronidazole is active against both bacteria and parasites.
Metronidazole is one of the rare examples of a drug developed against a parasite which has since gained broad use as an antibacterial agent (24). Briefly, at Rhone-Poulenc labs in France, extracts of Streptomyces spp. were screened for activity against Trichomonas vaginalis, a cause of vaginal itching. Azomycin, a nitroimidazole, was identified, and metronidazole, a synthetic derivative, was us...
متن کاملMetronidazole-triazole conjugates: Activity against Clostridium difficile and parasites
Metronidazole has been used clinically for over 50 years as an antiparasitic and broad-spectrum antibacterial agent effective against anaerobic bacteria. However resistance to metronidazole in parasites and bacteria has been reported, and improved second-generation metronidazole analogues are needed. The copper catalysed Huigsen azide-alkyne 1,3-dipolar cycloaddition offers a way to efficiently...
متن کاملGramicidin S is active against both gram-positive and gram-negative bacteria.
Four linear and four cyclic analogs of gramicidin S (GS) in which D-Phe was replaced with either D-His, D-Ser, D-Tyr or D-Asn have been prepared by solid-phase peptide synthesis and characterized with respect to antibacterial, antifungal and hemolytic activity. Unlike previous reports, GS and a number of cyclic analogs were found to be active against gram-positive as well as gram-negative bacte...
متن کاملBacteriocins active against plant pathogenic bacteria.
Gram-negative phytopathogens cause significant losses in a diverse range of economically important crop plants. The effectiveness of traditional countermeasures, such as the breeding and introduction of resistant cultivars, is often limited by the dearth of available sources of genetic resistance. An alternative strategy to reduce loss to specific bacterial phytopathogens is to use narrow-spect...
متن کاملScreening for antibiotics active against intracellular bacteria.
A large number of useful antibiotics have been discovered since the isolation of tyrothricin in 1939, yet as time passes and as the number of known antibiotics increases, their rediscovery becomes more and more fre(uent. Improvements in screening techniques are therefore indicated to eliminate undesired antibiotics with a minimum of labor. New techniques should also attempt to recognize biologi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1999
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.43.7.1533